Ayako Moritomo: search on Z-Library

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1

Use of Benford's law in drug discovery data

Masaya Orita, Ayako Moritomo, Tatsuya Niimi, Kazuki Ohno

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 314 KB

english, 2010

2

Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro

Journal:

Bioorganic & Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.04 MB

english, 2019

3

Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus

Koike, Takanori, Shiraki, Ryota, Sasuga, Daisuke, Hosaka, Mitsuru, Kawano, Tomoaki, Fukudome, Hiroki, Kurosawa, Kazuo, Moritomo, Ayako, Mimasu, Shinya, Ishii, Hirofumi, Yoshimura, Seiji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2019

Language:

english

File:

PDF, 2.77 MB

english, 2019

4

Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists

Moritomo, Ayako, Yamada, Hiroyoshi, Watanabe, Toshihiro, Itahana, Hirotsune, Akuzawa, Shinobu, Okada, Minoru, Ohta, Mitsuaki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

5

Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists

Nagashima, Shinya, Matsushima, Yuji, Hamaguchi, Hisao, Nagata, Hiroshi, Kontani, Toru, Moritomo, Ayako, Koshika, Tadatsura, Takeuchi, Makoto

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

6

Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor

Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Sugano, Yukihito, Yamaki, Susumu, Moritomo, Ayako, Kubo, Satoshi, Nakamura, Koji, Yamagami, Kaoru, Hamakawa, Nozomu, Yokoo, Koji, Fukahori, Hidehiko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 570 KB

english, 2018

7

Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Synthesis and structure–activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives

Naoyuki Masuda, Osamu Yamamoto, Masahiro Fujii, Tetsuro Ohgami, Jiro Fujiyasu, Toru Kontani, Ayako Moritomo, Masaya Orita, Hiroyuki Kurihara, Hironobu Koga, Shunji Kageyama, Mitsuaki Ohta, Hiroshi Ino

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 240 KB

english, 2005

8

Cs$^{+}$ Trapping in Size-Controlled Nanospaces of Hexacyanoferrates

Omura, Ayako, Moritomo, Yutaka

Journal:

Applied Physics Express

Year:

2012

Language:

english

File:

PDF, 690 KB

english, 2012

9

Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides

Naoyuki Masuda, Osamu Yamamoto, Masahiro Fujii, Tetsuro Ohgami, Jiro Fujiyasu, Toru Kontani, Ayako Moritomo, Masaya Orita, Hiroyuki Kurihara, Hironobu Koga, Hideaki Nakahara, Shunji Kageyama, Mitsuaki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 424 KB

english, 2004

10

Design, synthesis, and evaluation of 4,6-diaminonicotinamide derivatives as novel and potent immunomodulators targeting JAK3

Nakajima, Yutaka, Aoyama, Naohiro, Takahashi, Fumie, Sasaki, Hiroshi, Hatanaka, Keiko, Moritomo, Ayako, Inami, Masamichi, Ito, Misato, Nakamura, Koji, Nakamori, Fumihiro, Inoue, Takayuki, Shirakami, S

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.00 MB

english, 2016

11

Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors

Yamaki, Susumu, Suzuki, Daisuke, Fujiyasu, Jiro, Neya, Masahiro, Nagashima, Akira, Kondo, Mitsuhiro, Akabane, Takafumi, Kadono, Keitaro, Moritomo, Ayako, Yoshihara, Kosei

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.01 MB

english, 2017

12

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: Part 2

Inoue, Takayuki, Morita, Masataka, Tojo, Takashi, Nagashima, Akira, Moritomo, Ayako, Imai, Keisuke, Miyake, Hiroshi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

13

Oxidization Process of Fe–Ni Mixed Prussian Blue Analogue Investigated by Valence-Differential Spectroscopy

Omura, Ayako, Kurihara, Yutaro, Ishizaki, Manabu, Kurihara, Masato, Moritomo, Yutaka

Journal:

Japanese Journal of Applied Physics

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

14

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor

Hamaguchi, Hisao, Amano, Yasushi, Moritomo, Ayako, Shirakami, Shohei, Nakajima, Yutaka, Nakai, Kazuo, Nomura, Naoko, Ito, Misato, Higashi, Yasuyuki, Inoue, Takayuki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.35 MB

english, 2018

15

Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists

Kenji Negoro, Yasuhiro Yonetoku, Ayako Moritomo, Masahiko Hayakawa, Kazuhiko Iikubo, Shigeru Yoshida, Makoto Takeuchi, Mitsuaki Ohta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.97 MB

english, 2012

16

Discovery of 3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one derivatives as novel JAK inhibitors

Yamagishi, Hiroaki, Shirakami, Shohei, Nakajima, Yutaka, Tanaka, Akira, Takahashi, Fumie, Hamaguchi, Hisao, Hatanaka, Keiko, Moritomo, Ayako, Inami, Masamichi, Higashi, Yasuyuki, Inoue, Takayuki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

17

Agreement of drug discovery data with Benford's law

Orita, Masaya, Hagiwara, Yosuke, Moritomo, Ayako, Tsunoyama, Kazuhisa, Watanabe, Toshihiro, Ohno, Kazuki

Journal:

Expert Opinion on Drug Discovery

Year:

2013

Language:

english

File:

PDF, 381 KB

english, 2013

18

Cation Extraction Process in Bilayer Cyanide Film as Investigated by Depth-Resolved X-ray Absorption Spectroscopy

Omura, Ayako, Kurihara, Yutaro, Matsuda, Tomoyuki, Tanida, Hajime, Uruga, Tomoya, Moritomo, Yutaka

Journal:

Japanese Journal of Applied Physics

Year:

2011

Language:

english

File:

PDF, 250 KB

english, 2011

19

Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors

Shinya Nagashima, Takeshi Hondo, Hiroshi Nagata, Takashi Ogiyama, Jun Maeda, Hiroaki Hoshii, Toru Kontani, Sadao Kuromitsu, Keiko Ohga, Masaya Orita, Kazuki Ohno, Ayako Moritomo, Koichi Shiozuka, Masa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.28 MB

english, 2009

20

Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor

Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Sugano, Yukihito, Yamaki, Susumu, Suzuki, Daisuke, Moritomo, Ayako, Kubo, Satoshi, Nakamura, Koji, Yamagami, Kaoru, Yokoo, Koji, Fukahori, Hidehiko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.02 MB

english, 2019

21

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema

Inoue, Takayuki, Morita, Masataka, Tojo, Takashi, Yoshihara, Kousei, Nagashima, Akira, Moritomo, Ayako, Ohkubo, Mitsuru, Miyake, Hiroshi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

22

Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists

Moritomo, Ayako, Yamada, Hiroyoshi, Matsuzawa-Nomura, Takaho, Watanabe, Toshihiro, Itahana, Hirotsune, Oku, Makoto, Akuzawa, Shinobu, Okada, Minoru

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.53 MB

english, 2014

23

Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors

Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Mukoyoshi, Koichiro, Yoshihara, Kousei, Yamaki, Susumu, Sugano, Yukihito, Moritomo, Ayako, Yamagami, Kaoru, Yokoo, Koji, Fukahori, Hidehiko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.30 MB

english, 2018

24

Synthesis and pharmacological evaluation of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition

Yamaki, Susumu, Koga, Yuji, Nagashima, Akira, Kondo, Mitsuhiro, Shimada, Yoshiaki, Kadono, Keitaro, Moritomo, Ayako, Yoshihara, Kosei

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.12 MB

english, 2017

25

Regioselective Alkylation of Thiazolylsulfonamides: Direct and Efficient Synthesis of 3‐Alkylthiazolidene Derivatives

Masuda, Naoyuki, Yamamoto, Osamu, Fujii, Masahiro, Ohgami, Tetsuro, Moritomo, Ayako, Kontani, Toru, Kageyama, Shunji, Ohta, Mitsuaki

Journal:

Synthetic Communications

Year:

2005

Language:

english

File:

PDF, 129 KB

english, 2005

26

Regioselective Alkylation of Thiazolylsulfonamides: Direct and Efficient Synthesis of 3-Alkylthiazolidene Derivatives.

Naoyuki Masuda, Osamu Yamamoto, Masahiro Fujii, Tetsuro Ohgami, Ayako Moritomo, Toru Kontani, Shunji Kageyama, Mitsuaki Ohta

Journal:

Year:

2006

File:

PDF, 24 KB

2006

27

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors

Yamagishi, Hiroaki, Inoue, Takayuki, Nakajima, Yutaka, Maeda, Jun, Tominaga, Hiroaki, Usuda, Hiroyuki, Hondo, Takeshi, Moritomo, Ayako, Nakamori, Fumihiro, Ito, Misato, Nakamura, Koji, Morio, Hiroki,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.30 MB

english, 2017

28

ChemInform Abstract: Small-World Phenomena in Chemical Library Networks: Application to Fragment-Based Drug Discovery.

Naoki Tanaka, Kazuki Ohno, Tasuya Niimi, Ayako Moritomo, Kenichi Mori, Masaya Orita

Journal:

Year:

2010

File:

PDF, 15 KB

2010

29

Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment

Inoue, Takayuki, Morita, Masataka, Tojo, Takashi, Nagashima, Akira, Moritomo, Ayako, Miyake, Hiroshi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.44 MB

english, 2013

30

Small-World Phenomena in Chemical Library Networks: Application to Fragment-Based Drug Discovery

Tanaka, Naoki, Ohno, Kazuki, Niimi, Tatsuya, Moritomo, Ayako, Mori, Kenichi, Orita, Masaya

Journal:

Journal of Chemical Information and Modeling

Year:

2009

Language:

english

File:

PDF, 411 KB

english, 2009

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